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By Michael Lowder, DVM, MS

One basic component of any good horse health program is a complete vaccination program. The wide availability of products behooves the equestrian to inquire which vaccines are necessary to maintain their horse's health. A vaccination schedule should be tailored to provide maximal protection when disease risk is highest.

Vaccinating at specific times during the year may more readily prevent specific diseases than at other times. For example, a vector-transmitted disease would necessitate vaccination before the vector season. Other considerations of a vaccination program are pregnancy, age, environment, geographic location, disease prevalence, and use of the horse (e.g., broodmare).

This series of articles discusses options for disease prevention in horses. An effective immunization program reduces the occurrence of contagious and non-contagious diseases (such as tetanus).

When designing a vaccination protocol, one should remember that the success of the preventive herd health program is no better than the health of the individuals within the herd. Consequently, the introduction of horses of unknown immunization to the farm should be restricted until proper confirmation of immunization is assured. All vaccinations should be given at least three weeks prior to arrival at a new farm.

The interstate transportation of horses to shows and sales should also strongly influence a vaccination program. Horsemen should be familiar with the geographic distribution of diseases that could alter the standard vaccination protocol in their area.

Often, vaccination is perceived as complete, instant protection. Unfortunately, this is not true. After vaccination, the body takes two to four weeks to produce protective antibodies against the vaccinated disease(s). Animals vaccinated for the first time against a specific disease require a second vaccination two to four weeks later to strengthen the protective response.

Few vaccines offer total protection. Others offer partial, if not questionable, protection against some diseases. Some seem to reduce the severity of the disease but do not necessarily prevent it. The length of protection may vary with the type of vaccine used (e.g., killed versus modified-live).

One common failure of a horse health program is inaccurate record keeping. Documentation of immunization is essential to ensure success of the vaccination program. Marketing horses with documented immunization is easier and benefits the reputation of the equestrian.

Vaccines are currently available in the United States for the following diseases: tetanus; rhinopneumonitis; Eastern, Western, and Venezuelan encephalomyelitis; rabies; influenza; Potomac horse fever; strangles; botulism; equine viral arteritis; West Nile virus, and anthrax.

Vaccines may be monovalent (containing only one organism or antigen) or polyvalent (containing more than one virus) and contain either killed or modified-lived organisms. Basic guidelines for administration of vaccines in mature horses, broodmares, and foals, are presented in Tables I, II, and III. (see below)

Anthrax:
Anthrax is a bacterial disease that varies in presentation with the mode of infection. Horses most commonly show septicemia, enteritis and colic. Anthrax is caused by the organism Bacillus anthracis. Distribution of the disease is worldwide, but it is not commonly reported in the United States.

Vaccination is only recommended in enzootic areas of the country (i.e., South Dakota, Louisiana, Texas, Missouri, California, and Arkansas). Most cases of anthrax are reported during the warm summer months, but the disease may occur in the winter. In the case of an outbreak, only those animals not exhibiting clinical signs should be vaccinated. The equestrian should consult with their local veterinarian, as this is not a commonly given vaccine.

Botulism:
Botulism is a neuroparalytic disease caused by the organism Clostridium botulinum. It is geographically enzootic in some areas of the world. In North America, type B is most commonly found in the Mid-Atlantic States and Kentucky. Type A is prevalent west of the Rocky Mountains, and type C arises mainly in Florida.

Most foals are infected via growth of the bacterium within the gastrointestinal tract (toxicoinfectious botulism) between two weeks and eight months of age. Affected foals are referred to as having "shaker foal syndrome." Adult horses are most commonly infected via ingestion of preformed toxins referred to as "forage poisoning." Clinically, horses develop a progressive muscle paralysis that affects the limbs, jaw and throat muscles, the upper eyelid, tongue, and tail. It should be noted that the vaccine only offers protection against type B.

Table I - Vaccination Guidelines for Mature Horses
Table II - Vaccination Guidelines for Broodmares
Table III - Vaccination Guidelines for Foals, Weanlings & Yearlings

The other three parts of the vaccination guidelines will be coming in the next few weeks.


By Michael Lowder, DVM, MS

In Part II, we examine some of the most fatal diseases your horse may encounter.

Encephalomyelitis
Encephalomyelitis is a viral disease of horses. The three types are eastern, western, and Venezuelan. Various neurologic signs, including excitement, dementia, head pressing, and circling, characterize the disease.

Transmission occurs by vectors (i.e., mosquitoes), and the disease is generally associated with areas inhabited by these vectors and where winter temperatures are usually not severe.  Vaccination before vector season and biannually in humid areas of the country is recommended. The vaccine for encephalomyelitis is often polyvalent in combination with tetanus toxoid, influenza, or other vaccines. It is important to note that vaccination with the Venezuelan type mayinterfere with exportation of horses to some European countries because of seroconversion.

Equine Viral Arteritis
Equine viral arteritis is a viral disease caused by a arterivirus that can cause respiratory disease and abortion in horses. The vaccine is only recommended for use in stallions, open mares, and young horses six weeks of age or older. Pregnant mares and open mares or stallions that are within three weeks of being bred should not be vaccinated. Vaccination may interfere with exportation to some countries because of sero-conversion. Before using the vaccine, veterinarians/horsemen should check with their state veterinarian because some states regulate its use.

Influenza
Influenza is a viral disease that affects the upper respiratory tract of horses. Vaccination with a killed virus vaccine requires frequent administration (every two to six months) to provide appropriate protection to susceptible horses. A modified-live virus intranasal vaccine is also currently available.

The vaccine is available in monovalent or polyvalent forms. A transient postvaccinal fever occurs in some horses. Other horses also may show a loss of appetite and depression after vaccination. Once a horse is infected, the upper respiratory tract takes three weeks after remission of the disease to recover fully. Thus, the significance of immunizing the competitive and/or show horse to prevent costly layoff is apparent. In addition, it is equally important to vaccinate horses traveling to and from sales and breeding farms.

Current recommended vaccination schedules are every six months for adult horses at low to moderate risk and every one to three months for high-risk animals. Vaccinations should not be administered two to three weeks before a stressful event, such as a show, because of the increased chance of the previously mentioned side effects.

Potomac Horse Fever
Potomac horse fever (equine monocytic ehrlichiosis) is caused by E. risticii. The disease is characterized by diarrhea, ileus, and often laminitis. The disease has been reported mainly in the northeastern United States and Canada but has occurred in other countries. The disease is seasonal and usually occurs in late spring to early fall. As soon as Potomac horse fever occurs on a farm, there is a high risk of recurrence.

A freshwater snail is suspected to play a role in the transmission of the disease. Current vaccines offer short-term protection, and revaccination every six to twelve months is recommended. If an infected horse survives, it will maintain immunity for about two years, and should not require immediate revaccination. Vaccine failure has been reported in endemic areas.

Rabies
Rabies is a rhabdovirus that causes neurologic disease. The disease can cause a large variation in clinical signs that range from lethargy to bizarre, frightening behavior. Horses in enzootic areas should be vaccinated, especially those exposed to wildlife.

In some horses, a local tissue reaction occurs, and thus intramuscular vaccination is recommended in the lower thigh, not in the neck. Some vaccines of this type can be given subcutaneously (just under the skin). Vaccinated horses that are exposed to a rabid animal should be revaccinated and observed for 45 days. A licensed veterinarian should examine the horse at the initial time of injury and perform follow-up evaluations.

Rabies is invariably fatal in unvaccinated horses, and it is zoonotic; therefore, unvaccinated horses exposed to a rabid animal should be euthanized. Vaccination of unvaccinated horses after exposure to the disease is not recommended.

Owners unwilling to have their horse euthanized should isolate and closely observe the animal for six months. This isolation must occur under the authority of the rabies control agency. Illness or behavioral change must be reported the local rabies control agency immediately, and the horse must be evaluated by a veterinarian. If clinical signs are suggestive of rabies, euthanasia of the animal is required for rabies testing.

Rabies is the one disease that I insist that my clients vaccinate for.

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